AI Meets Cardiology: Bayosthiti and Narayana Partner to Predict Heart Disease in Indian Patients

Bayosthiti AI, an innovator in AI-driven healthcare and molecular diagnostics, announced a strategic partnership with Narayana Health, one of the world's largest cardiac care networks, to develop AI models that predict cardiovascular disease in Indian patients. The collaboration leverages RNA sequencing to read the active molecular instructions in cells, combined with gen AI to identify heart disease risk earlier and more accurately than conventional methods.

The study will analyze transcriptomic data (the complete set of active cellular RNA messages) from over 12,000 participants at Narayana Institute of Cardiac Sciences in Bengaluru. Using Bayosthiti's proprietary BIRT™ technology, researchers will sequence complete RNA profiles from patient blood samples to train AI models. These models will be capable of detecting distinctive patterns of cellular activity that signal coronary artery disease (blockages in heart arteries) before traditional tests show abnormalities.

Coronary artery disease affects 65 million Indians and strikes at younger ages than in Western populations. Yet, diagnostic tools remain largely calibrated to European and American patient data, creating what clinicians call the "Data Gap." Standard risk scores miss critical patterns in South Asian biology shaped by distinct genetic backgrounds and environmental factors, leading to late-stage diagnoses when intervention options narrow.

Bayosthiti AI and Narayana Health are solving this through molecular innovation and clinical scale. Narayana performs over 60,000 cardiac procedures annually, generating rich clinical data. Bayosthiti's BIRT™ (Barcode-Integrated Reverse Transcription) technology sequences complete RNA profiles at a fraction of traditional costs by processing multiple patient samples in parallel. This breakthrough makes it economically viable to build the massive datasets required to train robust AI models tailored for Indian populations, ensuring highly accurate and individualized genetic analysis.

Current diagnostics rely on anatomical imaging or protein markers, both of which detect disease after it has physically manifested. RNA sequencing captures the dynamic instructions cells are executing in real time. By analyzing which genetic instructions are being transcribed (actively used to make proteins) and at what levels, Bayosthiti's AI can detect when biological systems shift toward disease states, potentially months or years before structural damage appears.

"Just as Google Translate learned language patterns from billions of text examples, our AI learns disease patterns from millions of RNA expressions," said Dr. Rishabh M. Shetty, Head of Business Development and Clinical Applications at Bayosthiti AI. "The transcriptome gives us a real-time readout of what the body is doing right now. Our models can spot the molecular conversation that precedes a heart attack, not just the aftermath, and can do so with the same level of accuracy and efficacy as invasive procedures or other current imaging gold standards."

The clinical credibility matters. Narayana Health's scale and reputation make it an ideal validation partner. Its leadership views AI integration as the next frontier in expanding access and improving outcomes. "AI-based technologies aren't the future of medicine. They're the present," said Dr. P.M. Uthappa, Group Chief Medical Director at Narayana Health. "This collaboration lets us move from intervention to prevention. The ability to identify high-risk patients earlier and more precisely is a clinical game-changer."

The partnership builds on Bayosthiti's momentum since establishing operations in India. The company has processed samples from over 100 collaborations globally, and this study represents a significant expansion in both scope and strategic importance.

"We've relied too long on a one-size-fits-all approach to medicine," said Kutapa Muthanna, CEO of Bayosthiti AI. "This isn't just about closing a data gap. It's about building the foundation for proactive, personalized medicine created by Indians, for Indians. When we can tell someone their heart disease risk is rising before any scan shows blockage, we transform care from reactive to preventive."

The three-phase study design allows for continuous improvement. Successfully validating these AI models would provide proof-of-concept for deploying similar approaches for other high-burden diseases in India. As the partnership progresses, findings will inform the development of a blood-based diagnostic test deployable at scale across India's healthcare system.

About Bayosthiti AI

Bayosthiti AI, a wholly-owned subsidiary of US-based Biostate AI, is India’s first AI-first healthcare company pioneering Lifetime Health Management. By integrating patented BIRT™ and other cutting-edge molecular technologies with advanced generative AI, Bayosthiti is building a foundational health-tech platform for India. This platform includes 24/7 AI Clinical Assistants and AI Scientists for patients, clinicians, and researchers, making personalized precision care a reality for all.

For more information, visit https://bayosthiti.ai/.

About Narayana Hrudayalaya

Narayana Hrudayalaya, operating under the brand name Narayana Health, is one of India’s leading private healthcare service providers. The group operates a nationwide network of hospitals with a mission to deliver high-quality, safe and technology-enabled healthcare to the broader population. Renowned globally for its expertise in Cardiac Sciences, Narayana Health has been at the forefront of heart care for over two decades, performing one of the highest volumes of cardiac procedures in the world.

As the only hospital group in India with Enterprise-level Joint Commission International (JCI) accreditation, Narayana Health upholds the highest standards of quality and patient safety across its network. Guided by its core values of Quality, Compassion, and Innovation, Narayana Health remains committed to its vision of ‘Health for all. All for Health.’

For more information, visit narayanahealth.org.

Jaslok Hospital Partners with AnginaX AI to Launch Maharashtra’s First Operational AI-Powered Heart Disease Prevention Model

In a landmark initiative that could redefine how India tackles its leading cause of death, Jaslok Hospital & Research Centre has partnered with AnginaX AI, India’s first licensed AI Doctor Assistant in cardiology, to launch Maharashtra’s first operational AI-powered heart disease prevention model.

This collaboration places Jaslok at the forefront of India’s shift from late-stage cardiac intervention to early, technology-driven prevention. The advanced AnginaX AI system, now deployed across Jaslok’s outpatient departments, enables doctors to assess cardiovascular risk in just seconds using structured, science-backed reports that identify risk even before symptoms appear and recommend personalized lifestyle and treatment plans.

With heart disease affecting millions of Indians and often going undetected until it’s too late, this prevention model brings speed, clarity, and access to the very first point of contact: the OPD.

“For decades, cardiology has focused on damage control.” said Padma Bhushan Awardee Dr. Ashwin B. Mehta, Director of Cardiology at Jaslok Hospital. “But with advanced AI, we can now assess who is at risk before damage begins. This is not just innovation, but reimagining the timeline of care."

The AnginaX system evaluates more than 20 critical clinical and lifestyle-based indicators, including extended lipid profiles, blood sugar, inflammatory biomarkers, metabolic complexities, family history, and lifestyle patterns. Based on validated Indian data, the system generates a structured clinical summary that includes individualized risk stratification, investigation recommendations specific to each patient, and clear, actionable treatment and follow-up guidance.

“The AnginaX AI system gives us clinical clarity in under a minute, especially vital in high-volume OPD settings.” said Dr. Ajit Desai, Senior Cardiologist at Jaslok. “We’re now able to consult more patients, detect silent risks early, and guide people to act before their first symptom.”

Recognizing that cost and fear are often barriers to early checkups, Jaslok and AnginaX have ensured the program is fast, accessible and affordable, making prevention routine rather than rare.

“This isn’t just about digital transformation, but about medical timing,” said Mr. Jitendra Haryan, CEO of Jaslok Hospital. “Our hospital is proud to lead this change in India’s healthcare system. When technology and medicine work together, lives are saved earlier.”

Jaslok also launched AI-powered initiative “Dil Fit, Life Hit” under the leadership of Dr. Ashwin B. Mehta, bringing structured cardiovascular prevention into everyday clinical care. The program empowers doctors, transforms OPD practice, and makes prevention accessible to every patient, not just those with symptoms.

Naman Gosalia, Founder of AnginaX AI, added: “We’ve built an advanced AI medical system that fits seamlessly into any hospital or clinic, helping doctors halt the progression of cardiovascular disease through precision-led risk assessment and personalized treatment recommendations. Our mission is to bring primary prevention to every clinic, every hospital and every corner of India without disrupting how doctors practice.”

“The KPI of this model was simple: could it work on my own mother? We made a clear decision that we would only release it if it worked on her. We tested it on our mother first before going into the pilot. That trial was successful and it gave us the conviction to move forward.” he said.

“Launching it at Jaslok and having their leadership activate it first in Maharashtra, reflects a shared belief that people deserve better outcomes, and prevention should not come with fear, friction, or financial burden. This partnership helps us put the patient first and take this mission to scale across India.”

Dr. Neeraj Desai, Strategic Medical Advisor at AnginaX AI said, “AnginaX AI system is a bridge between data and decision, between missed chances and timely care. In medicine, timing is everything. And for the first time, we are putting timing on the side of prevention”. 

AI-based screening has already begun at Jaslok. Doctors are now taking swift, informed preventive steps, especially for patients who might otherwise remain undiagn

Human Heart can Change Shape when People Don’t Do Endurance Exercise

Human hearts have evolved for Endurance, and we need it to stay healthy, suggests a new study comparing the hearts of humans, chimpanzees and gorillas, which found that the human heart can change shape to reflect more of a chimpanzee like structure when people don’t do endurance exercise.

Endurance is that ability of an organism/humans to exert and remain active for a long period of time, as well as its ability to resist, withstand, recover from, and have immunity to trauma, wounds, or fatigue.

According to new study published this week in the journal PNAS, one of the world's most-cited and comprehensive multidisciplinary scientific journals, the human heart remodels throughout the lifetime in response to a person's activity.

Human heart can change shape to reflect more of a chimplike structure when people don't do endurance exercise, says the study by research led by Aaron Baggish, along with a team of co-authors that includes Daniel Lieberman, a human evolutionary biologist at Harvard, and Robert Shave, a cardiovascular physiologist at the University of British Columbia Okanagan.



Baggish and team compared the shape and activity of the hearts of chimpanzees, gorillas and and four groups of adult humans -- endurance athletes, football linemen, subsistence farmers and relatively inactive individuals.

The researchers found that the hearts of both the football linemen and sedentary individuals experienced remodeling that made their hearts less adapted to responding to endurance challenges and more adapted to responding to pressure. The walls became thicker, and the heart didn't twist as well.

The researchers also studied four groups of people with different exercise and activity patterns. One group was composed of 42 people from the Tarahumara, a group of indigenous people from Mexico who are known for their distance running events, although Shave said the vast majority of the time they are not doing high intensity exercise. The ventricles in their hearts did not have as large a volume as the researchers found in the 42 endurance athletes the group studied. The team also studied 40 people who played the position of lineman in American football, and a group of 42 relatively sedentary people.

[blockquote footer=""]There’s one additional significant difference between the hearts of humans and apes. When human hearts pump, they also rotate. This twist helps push more blood out each time it beats, and also draw more blood in for the next time it pumps.[/blockquote]

The study emphasizes the importance of regular exercise. A modern diet could complicate the picture, but regular walking could be sufficient -- previous research showed that hunter-gatherers in tropical areas tend to walk roughly 6-9 miles every day. A hunter-gatherer is a human living in a society in which most or all food is obtained by foraging (collecting wild plants and pursuing wild animals).

"Humans have evolved this extraordinary long lifespan in comparison to most other species," said Shave. "But to maintain a healthy blood pressure, we need to maintain that moderate intensity physical activity throughout our lives."

Via ~ InsideScience.org